Anti-PLA2R/PLA2R1 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Secretory phospholipase A2 receptor is an enzyme that in humans is encoded by the PLA2R1 gene. This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms
Interleukin-25; IL-25; Interleukin-17E; IL-17E; IL25; IL17E; UNQ3120/PRO10272
Gene Name
PLA2R1
Gene ID
22925
UniProt
Q13018
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human PLA2R/PLA2R1 recombinant protein (Position: E21-Q66) .
Clonality
Polyclonal
Tissue Specificity
Expressed at low levels in several tissues, including brain, kidney, lung, prostate, testis, spinal cord, adrenal gland, and trachea.
Applications
Flow Cytometry
Field of Research
Cytokines, Immunology, Innate Immunity, Interleukins
Purification
Immunogen affinity purified.
Form
Liquid
Function
Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses.
References & Citations
1. Ancian, P., Lambeau, G., Mattei, M.-G., Lazdunski, M. The human 180-kDa receptor for secretory phospholipases A2: molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization. J. Biol. Chem. 270: 8963-8970, 1995. 2. Beck, L. H., Jr., Bonegio, R. G. B., Lambeau, G., Beck, D. M., Powell, D. W., Cummins, T. D., Klein, J. B., Salant, D. J. M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. New Eng. J. Med. 361: 11-21, 2009. 3. Debiec, H., Ronco, P. PLA2R autoantibodies and PLA2R glomerular deposits in membranous nephropathy. (Letter) New Eng. J. Med. 364: 689-690, 2011.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Interleukin 25
Subcellular Location
Secreted.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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