Anti-MAP2 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Microtubule-associated protein 2 is a protein that in humans is encoded by the MAP2 gene. This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described.
Synonyms
Microtubule-associated protein 2; MAP-2; MAP2
Gene Name
MAP2
Gene ID
4133
UniProt
P11137
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human MAP2 recombinant protein (Position: A360-E1101) .
Clonality
Polyclonal
Applications
Flow Cytometry
Field of Research
Cell Type Marker, Cytoskeleton, Cytoskeleton/ECM, Microtubules, Neural Stem Cells, Neuron Marker, Neuroscience, Signal Transduction, Stem Cells
Purification
Immunogen affinity purified.
Form
Liquid
Function
The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
References & Citations
1. Kalcheva N, Albala J, O'Guin K, Rubino H, Garner C, Shafit-Zagardo B (December 1995) . Genomic structure of human microtubule-associated protein 2 (MAP-2) and characterization of additional MAP-2 isoforms.Proc Natl Acad Sci U S A. 92 (24) : 10894–8. 2. Neve RL, Harris P, Kosik KS, Kurnit DM, Donlon TA (May 1987) . Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2. Brain Res. 387 (3) : 271–80.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Microtubule-associated protein 2
Subcellular Location
Cytoplasm, cytoskeleton. Cell projection, dendrite.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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