Anti-NTAL/LAT2 Antibody Picoband®

Linker for activation of T-cells family member 2, also known as WBSCR5 or NTAL is a protein that in humans is encoded by the LAT2 gene. It is mapped to 7q11.23. It has been found that NTAL associated with GRB2, SOS1 and GAB1 after B-cell receptor activation. Phosphorylation of NTAL was strongest in the presence of LCK, ZAP70, SYK, or LYNLAT2. NTAL is a structural and possibly a functional homolog of LAT in non-T cells. It also has been found that BLNK and LAT2 in B cells are a functionally equivalent pair to SLP76 and LAT in T cells. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein.

Adaptive Immunity, Autoimmune, B Cells, Cytokines, Hematopoietic Progenitors, Immune System Diseases, Immunology, Innate Immunity, Lymphoid, Stem Cells, T Cells, T Lymphocytic Lineage, TNF Superfamily

1. Brdicka, T., Imrich, M., Angelisova, P., Brdickova, N., Horvath, O., Spicka, J., Hilgert, I., Luskova, P., Draber, P., Novak, P., Engels, N., Wienands, J., Simeoni, L., Osterreicher, J., Aguado, E., Malissen, M., Schraven, B., Horejsi, V. Non-T cell activation linker (NTAL) : a transmembrane adaptor protein involved in immunoreceptor signaling. J. Exp. Med. 1617-1626, 2002. 2. Doyle, J. L., DeSilva, U., Miller, W., Green, E. D. Divergent human and mouse orthologs of a novel gene (WBSCR15/Wbscr15) reside within the genomic interval commonly deleted in Williams syndrome. Cytogenet. Cell Genet. 90: 285-290, 2000. 3. Janssen, E., Zhu, M., Zhang, W., Koonpaew, S., Zhang, W. LAB: a new membrane-associated adaptor molecule in B cell activation. Nature Immun. 4: 117-123, 2003.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.