Anti-HSPA6 Antibody Picoband®

Heat shock 70 kDa protein 6 is a protein that in humans is encoded by the HSPA6 gene. HSPA6 (also known as HSP70B) is a member of the HSPA (HSP70) family of heat-shock proteins which are highly conserved chaperons implicated in protein folding, protein refolding, protein transport, and protein targeting. Human HSP70B is known to be strictly inducible and shows very low or no basal expression levels in most cells. HSPA6 induction has been exploited as a reasonable biomarker of cellular stresses and its mRNA expression levels have been shown to be significantly induced against a variety of cellular stresses. This antibody was raised against the C-terminal region of human HSPA6 and it may cross-react with HSPA1 (HSP70), HSPA1L and HSPA2.

RNA binding protein fox-1 homolog 2; Fox-1 homolog B; Hexaribonucleotide-binding protein 2; RNA-binding motif protein 9; RNA-binding protein 9; Repressor of tamoxifen transcriptional activity; RBFOX2; FOX2; HRNBP2; RBM9; RTA

Expressed in fetal brain. Highly expressed in brain and placenta. Lower levels in heart, liver, thymus, kidney and lung. Located to endothelial cells and neuronal cells of the suprachiasmatic nucleus (SCN) . Also detected in endothelial cells of the heart, lung and kidney. In the brain, specifically expressed in the thalamus, hippocampus and amygdala.

Cardiogenesis, Cardiovascular, Domain Families, Epigenetics and Nuclear Signaling, Hlh/Leucine Zipper, Neurology Process, Neuroscience, Receptors, Transcription, Transcription Factors, Transcription Factors/Regulators

RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis (By similarity) . RNA-binding protein that seems to act as a coregulatory factor of ER-alpha.

1. Brzustowicz, L. M., Hayter, J. E., Hodgkinson, K. A., Chow, E. W. C., Bassett, A. S. Fine mapping of the schizophrenia susceptibility locus on chromosome 1q22. Hum. Hered. 54: 199-209, 2002. 2. Grosz, M. D., Womack, J. E., Skow, L. C. Syntenic conservation of HSP70 genes in cattle and humans. Genomics 14: 863-868, 1992. 3. Leung, T. K. C., Hall, C., Rajendran, M., Spurr, N. K., Lim, L. The human heat-shock genes HSPA6 and HSPA7 are both expressed and localize to chromosome 1. Genomics 12: 74-79, 1992.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.