Anti-FHL2 Antibody Picoband® Fluoro488 Conjugated

Four and a half LIM domains protein 2 also known as FHL-2 is a protein that in humans is encoded by the FHL2 gene. This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants encoding different isoforms have been identified.

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.

1. Amaar, Y. G., Thompson, G. R., Linkhart, T. A., Chen, S.-T., Baylink, D. J., Mohan, S. Insulin-like growth factor-binding protein 5 (IGFBP-5) interacts with a four and a half LIM protein 2 (FHL2) . J. Biol. Chem. 277: 12053-12060, 2002. 2. Bai, S., Kitaura, H., Zhao, H., Chen, J., Muller, J. M., Schule, R., Darnay, B., Novack, D. V., Ross, F. P., Teitelbaum, S. L. FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner. J. Clin. Invest. 115: 2742-2751, 2005. 3. Chan, K. K., Tsui, S. K. W., Lee, S. M. Y., Luk, S. C. W., Liew, C. C., Fung, K. P., Waye, M. M. Y., Lee, C. Y. Molecular cloning and characterization of FHL2, a novel LIM domain protein preferentially expressed in human heart. Gene 210: 345-350, 1998.