Anti-CDC7 Antibody Picoband® Fluoro647 Conjugated

Cell division cycle 7-related protein kinase is an enzyme that in humans is encoded by the CDC7 gene. This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected.

1. Hess, G. F., Drong, R. F., Weiland, K. L., Slightom, J. L., Sclafani, R. A., Hollingsworth, R. E. A human homolog of the yeast CDC7 gene is overexpressed in some tumors and transformed cell lines. Gene 211: 133-140, 1998. 2. Jiang, W., Hunter, T. Identification and characterization of a human protein kinase related to budding yeast Cdc7p. Proc. Nat. Acad. Sci. 94: 14320-14325, 1997. 3. Kim, J. M., Sato, N., Yamada, M., Arai, K., Masai, H. Growth regulation of the expression of mouse cDNA and gene encoding a serine/threonine kinase related to Saccharomyces cerevisiae CDC7 essential for G (1) /S transition: structure, chromosomal localization, and expression of mouse gene for S. cerevisiae CDC7-related kinase. J. Biol. Chem. 273: 23248-23257, 1998. Note: Erratum: J. Biol. Chem. 273: 27755 only, 1998.