Anti-PACAP-38/ADCYAP1 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Pituitary adenylate cyclase-activating polypeptide also known as PACAP is a protein that in humans is encoded by the ADCYAP1 gene. This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants.
Synonyms
Fibroblast growth factor 10; FGF-10; Keratinocyte growth factor 2; FGF10
Gene Name
ADCYAP1
Gene ID
116
UniProt
P18509
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human PACAP-38/ADCYAP1, identical to the related mouse and rat sequences.
Clonality
Polyclonal
Tissue Specificity
Expressed in numerous tissues with highest level in testis.
Applications
Flow Cytometry
Field of Research
Organelles, Subcellular Markers, Tags & Cell Markers
Purification
Immunogen affinity purified.
Form
Liquid
Function
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing.
References & Citations
1. Dorus, S., Vallender, E. J., Evans, P. D., Anderson, J. R., Gilbert, S. L., Mahowald, M., Wyckoff, G. J., Malcom, C. M., Lahn, B. T. Accelerated evolution of nervous system genes in the origin of Homo sapiens. Cell 119: 1027-1040, 2004. 2. Freson, K., Hashimoto, H., Thys, C., Wittevrongel, C., Danloy, S., Morita, Y., Shintani, N., Tomiyama, Y., Vermylen, J., Hoylaerts, M. F., Baba, A., Van Geet, C. The pituitary adenylate cyclase-activating polypeptide is a physiological inhibitor of platelet activation. J. Clin. Invest. 113: 905-912, 2004. 3. Hamelink, C., Tjurmina, O., Damadzic, R., Young, W. S., Weihe, E., Lee, H.-W., Eiden, L. E. Pituitary adenylate cyclase-activating polypeptide is a sympathoadrenal neurotransmitter involved in catecholamine regulation and glucohomeostasis. Proc. Nat. Acad. Sci. 99: 461-466, 2002.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Fibroblast growth factor 10
Subcellular Location
Secreted.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS1172904-01 0.02 mg (E-Coli)
Recombinant Mycobacterium leprae Biotin synthase (bioB)
Ask
View Details