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Anti-MRP3/ABCC3 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Canalicular multispecific organic anion transporter 2 is a protein that in humans is encoded by the ABCC3 gene. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Synonyms

High affinity immunoglobulin gamma Fc receptor I; IgG Fc receptor I; Fc-gamma RI; FcRI; Fc-gamma RIA; FcgammaRIa; CD64; FCGR1A; FCG1; FCGR1; IGFR1

Gene Name

ABCC3

Gene ID

8714

UniProt

O15438

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human MRP3/ABCC3 recombinant protein (Position: F214-A275) .

Clonality

Polyclonal

Tissue Specificity

Monocyte/macrophage specific.

Applications

Flow Cytometry

Field of Research

Immunoglobulins, Immunology, Innate Immunity

Purification

Immunogen affinity purified.

Form

Liquid

Function

High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.

References & Citations

1. Belinsky, M. G., Bain, L. J., Balsara, B. B., Testa, J. R., Kruh, G. D. Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins. J. Nat. Cancer Inst. 90: 1735-1741, 1998. 2. Fromm, M. F., Leake, B., Roden, D. M., Wilkinson, G. R., Kim, R. B. Human MRP3 transporter: identification of the 5-prime flanking region, genomic organization and alternative splice variants. Biochim. Biophys. Acta 1415: 369-374, 1999. 3. Kiuchi, Y., Suzuki, H., Hirohashi, T., Tyson, C. A., Sugiyama, Y. cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3) . FEBS Lett. 433: 149-152,1998.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A02429-1-Fluoro647

Calculated Molecular Weight

38779 MW

Applications Notes

6

Gene Name Synonym

Fc fragment of IgG receptor Ia

Subcellular Location

Cell membrane.

Protein Name

BAG family molecular chaperone regulator 1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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