Anti-RBM28 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
RNA-binding protein 28 is a protein that in humans is encoded by the RBM28 gene. The protein encoded by this gene is a specific nucleolar component of the spliceosomal small nuclear ribonucleoprotein (snRNP) complexes . It specifically associates with U1, U2, U4, U5, and U6 small nuclear RNAs (snRNAs), possibly coordinating their transition through the nucleolus. Mutation in this gene causes alopecia, progressive neurological defects, and endocrinopathy (ANE syndrome), a pleiotropic and clinically heterogeneous disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms
B-cell differentiation antigen CD72; Lyb-2; CD72; CD72
Gene Name
RBM28
Gene ID
55131
UniProt
Q9NW13
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human RBM28 recombinant protein (Position: E18-K584) .
Clonality
Polyclonal
Tissue Specificity
Pre-B-cells and B-cells but not terminally differentiated plasma cells.
Applications
Flow Cytometry
Field of Research
Adaptive Immunity, B Cells, Hematopoietic Progenitors, Immunology, Lymphoid, Stem Cells
Purification
Immunogen affinity purified.
Form
Liquid
Function
Plays a role in B-cell proliferation and differentiation.
References & Citations
1. Damianov, A., Kann, M., Lane, W. S., Bindereif, A. Human RBM28p protein is a specific nucleolar component of the spliceosomal snRNPs. Biol. Chem. 387: 1455-1460, 2006. 2. Gross, M. B. Personal Communication. Baltimore, Md. 10/30/2017. 3. Nousbeck, J., Spiegel, R., Ishida-Yamamoto, A., Indelman, M., Shani-Adir, A., Adir, N., Lipkin, E., Bercovici, S., Geiger, D., van Steensel, M. A., Steijlen, P. M., Bergman, R., Bindereif, A., Choder, M., Shalev, S., Sprecher, E. Alopecia, neurological defects, and endocrinopathy syndrome caused by decreased expression of RBM28, a nucleolar protein associated with ribosome biogenesis. Am. J. Hum. Genet. 82: 1114-1121, 2008.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
CD72 molecule
Subcellular Location
Membrane; Single-pass type II membrane protein.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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