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Anti-PTGES2/Gbf1 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Microsomal prostaglandin E synthase-2 (mPGES-2) or Prostaglandin E synthase 2 is an enzyme that in humans encoded by the PTGES2 gene located on chromosome 9. The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE) . Multiple transcript variants have been found for this gene.

Synonyms

Neurocan core protein; Chondroitin sulfate proteoglycan 3; NCAN; CSPG3, NEUR

Gene Name

PTGES2

Gene ID

80142

UniProt

Q9H7Z7

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human PTGES2/Gbf1 recombinant protein (Position: L100-I370) .

Clonality

Polyclonal

Tissue Specificity

Brain.

Applications

Flow Cytometry

Field of Research

Cell Adhesion Proteins, ECM Proteins, Neuroscience

Purification

Immunogen affinity purified.

Form

Liquid

Function

May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM) . Chondroitin sulfate proteoglycan; binds to hyaluronic acid.

References & Citations

1. Hu, J., Meng, Q., Roy, S. K., Raha, A., Hu, J., Zhang, J., Hashimoto, K., Kalvakolanu, D. V. A novel transactivating factor that regulates interferon-gamma-dependent gene expression. J. Biol. Chem. 277: 30253-30263, 2002. 2. Nitz, I., Fisher, E., Grallert, H., Li, Y., Gieger, C., Rubin, D., Boeing, H., Spranger, J., Lindner, I., Schreiber, S., Rathmann, W., Gohlke, H., Doring, A., Wichmann, H.-E., Schrezenmeir, J., Doring, F., Illig, T. Association of prostaglandin E synthase 2 (PTGES2) arg298-to-his polymorphism with type 2 diabetes in two German study populations. J. Clin. Endocr. Metab. 92: 3183-3188, 2007. 3. Tanikawa, N., Ohmiya, Y., Ohkubo, H., Hashimoto, K., Kangawa, K., Kojima, M., Ito, S., Watanabe, K. Identification and characterization of a novel type of membrane-associated prostaglandin E synthase. Biochem. Biophys. Res. Commun. 291: 884-889, 2002.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

104553 MW

Applications Notes

6

Gene Name Synonym

Neurocan

Subcellular Location

Secreted .

Protein Name

AP-2 complex subunit beta

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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