Anti-PTGES2/Gbf1 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Microsomal prostaglandin E synthase-2 (mPGES-2) or Prostaglandin E synthase 2 is an enzyme that in humans encoded by the PTGES2 gene located on chromosome 9. The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE) . Multiple transcript variants have been found for this gene.
Synonyms
Neurocan core protein; Chondroitin sulfate proteoglycan 3; NCAN; CSPG3, NEUR
Gene Name
PTGES2
Gene ID
80142
UniProt
Q9H7Z7
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human PTGES2/Gbf1 recombinant protein (Position: L100-I370) .
Clonality
Polyclonal
Tissue Specificity
Brain.
Applications
Flow Cytometry
Field of Research
Cell Adhesion Proteins, ECM Proteins, Neuroscience
Purification
Immunogen affinity purified.
Form
Liquid
Function
May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM) . Chondroitin sulfate proteoglycan; binds to hyaluronic acid.
References & Citations
1. Hu, J., Meng, Q., Roy, S. K., Raha, A., Hu, J., Zhang, J., Hashimoto, K., Kalvakolanu, D. V. A novel transactivating factor that regulates interferon-gamma-dependent gene expression. J. Biol. Chem. 277: 30253-30263, 2002. 2. Nitz, I., Fisher, E., Grallert, H., Li, Y., Gieger, C., Rubin, D., Boeing, H., Spranger, J., Lindner, I., Schreiber, S., Rathmann, W., Gohlke, H., Doring, A., Wichmann, H.-E., Schrezenmeir, J., Doring, F., Illig, T. Association of prostaglandin E synthase 2 (PTGES2) arg298-to-his polymorphism with type 2 diabetes in two German study populations. J. Clin. Endocr. Metab. 92: 3183-3188, 2007. 3. Tanikawa, N., Ohmiya, Y., Ohkubo, H., Hashimoto, K., Kangawa, K., Kojima, M., Ito, S., Watanabe, K. Identification and characterization of a novel type of membrane-associated prostaglandin E synthase. Biochem. Biophys. Res. Commun. 291: 884-889, 2002.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
104553 MW
Applications Notes
6
Gene Name Synonym
Neurocan
Subcellular Location
Secreted .
Protein Name
AP-2 complex subunit beta
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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