Anti-GP210/NUP210 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a membrane-spanning glycoprotein that is a major component of the nuclear pore complex. Multiple pseudogenes related to this gene are located on chromosome 3.
Synonyms
Loricrin; LOR; LRN
Gene Name
NUP210
Gene ID
23225
UniProt
Q8TEM1
Host
Rabbit
Reactivity
Human, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human GP210/NUP210 recombinant protein (Position: R221-K1724) .
Clonality
Polyclonal
Tissue Specificity
Expressed in testis and to a lesser degree in brain, ovary and placenta. Found in most tissues at low levels.
Applications
Flow Cytometry
Field of Research
Cell Biology, Cytokines, Epigenetics and Nuclear Signaling, Immunology, Innate Immunity, Interferons, Proteasome / Ubiquitin, Proteolysis/Ubiquitin, Ubiquitin & Ubiquitin Like Modifiers, Ubiquitin E3 Enzymes
Purification
Immunogen affinity purified.
Form
Liquid
Function
Major keratinocyte cell envelope protein.
References & Citations
1. Favreau, C., Worman, H. J., Wozniak, R. W., Frappier, T., Courvalin, J.-C. Cell cycle-dependent phosphorylation of nucleoporins and nuclear pore membrane protein Gp210. Biochemistry 35: 8035-8044, 1996. 2. Nagase, T., Ishikawa, K., Suyama, M., Kikuno, R., Hirosawa, M., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N., Ohara, O. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 5: 355-364, 1998. 3. Olsson, M., Ekblom, M., Fecker, L., Kurkinen, M., Ekblom, P. cDNA cloning and embryonic expression of mouse nuclear pore membrane glycoprotein 210 mRNA. Kidney Int. 56: 827-838, 1999.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
39411 MW
Applications Notes
6
Gene Name Synonym
Loricrin
Subcellular Location
Nucleoplasm. Cytoplasm.
Protein Name
Zinc finger protein Helios
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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