Anti-GAS1 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Growth arrest-specific protein 1 is a protein that in humans is encoded by the GAS1 gene. Growth arrest-specific 1 plays a role in growth suppression. GAS1 blocks entry to S phase and prevents cycling of normal and transformed cells. Gas1 is a putative tumor suppressor gene.
Synonyms
Intraflagellar transport protein 88 homolog; Recessive polycystic kidney disease protein Tg737 homolog; Tetratricopeptide repeat protein 10; TPR repeat protein 10; IFT88; TG737; TTC10
Gene Name
GAS1
Gene ID
2619
UniProt
P54826
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human GAS1 recombinant protein (Position: L40-D288) .
Clonality
Polyclonal
Tissue Specificity
Expressed in the heart, brain, liver, lung, kidney, skeletal muscle and pancreas.
Applications
Flow Cytometry
Field of Research
Cell Adhesion Proteins, ECM Proteins, Neuroscience
Purification
Immunogen affinity purified.
Form
Liquid
Function
Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment.
References & Citations
1. Allen, B. L., Tenzen, T., McMahon, A. P. The hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development. Genes Dev. 21: 1244-1257, 2007. 2. Colombo, M. P., Martinotti, A., Howard, T. A., Schneider, C., D'Eustachio, P., Seldin, M. F. Localization of growth arrest-specific genes on mouse chromosomes 1, 7, 8, 11, 13, and 16. Mammalian Genome 2: 130-134, 1992. 3. Del Sal, G., Collavin, L., Ruaro, M. E., Edomi, P., Saccone, S., Della Valle, G., Schneider, C. Structure, function, and chromosome mapping of the growth-suppressing human homologue of the murine gas1 gene. Proc. Nat. Acad. Sci. 91: 1848-1852, 1994.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
104553 MW
Applications Notes
6
Gene Name Synonym
Intraflagellar transport 88
Subcellular Location
Centriole. Cilium basal body. Centrosome. Cilium. Cytoplasm. Flagellum.
Protein Name
AP-2 complex subunit beta
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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