Anti-FRK Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Fyn-related kinase (Frk) is a tyrosine kinase of the Src family. Also known as Rak, Gtk, and Iyk, Frk is predominantly expressed in epithelial tissues. Frk protein is 49% and 47% identical to Fyn and Csk, respectively. Src family kinases regulate an array of cellular processes, including growth factor signaling, cytoskeleton dynamics, and cell proliferation.
Synonyms
Carbonic anhydrase 12; Carbonate dehydratase XII; Carbonic anhydrase XII; CA-XII; Tumor antigen HOM-RCC-3.1.3; CA12
Gene Name
FRK
Gene ID
2444
UniProt
P42685
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human FRK recombinant protein (Position: Q39-A339) .
Clonality
Polyclonal
Tissue Specificity
Highly expressed in colon, kidney, prostate, intestine and activated lymphocytes. Expressed at much higher levels in the renal cell cancers than in surrounding normal kidney tissue. Moderately expressed in pancreas, ovary and testis. Expressed in sweat glands and bronchiolar epithelium (PubMed:26911677) .
Applications
Flow Cytometry
Field of Research
Cancer, Cardiovascular, Energy Metabolism, Energy Transfer Pathways, Metabolic Signaling Pathways, Metabolism, Oxidative Stress, Pathways and Processes, Redox Metabolism, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Reversible hydration of carbon dioxide.
References & Citations
1. Anneren, C., Reedquist, K. A., Bos, J. L., Welsh, M. GTK, a Src-related tyrosine kinase, induces nerve growth factor-independent neurite outgrowth in PC12 cells through activation of the Rap1 pathway: relationship to Shb tyrosine phosphorylation and elevated levels of focal adhesion kinase. J. Biol. Chem. 275: 29153-29161, 2000. 2. Cance, W. G., Craven, R. J., Bergman, M., Xu, L., Alitalo, K., Liu, E. T. Rak, a novel nuclear tyrosine kinase expressed in epithelial cells. Cell Growth Differ. 5: 1347-1355, 1994. 3. Cance, W. G., Craven, R. J., Weiner, T. M., Liu, E. T. Novel protein kinases expressed in human breast cancer. Int. J. Cancer 54: 571-
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
17184 MW
Applications Notes
6
Gene Name Synonym
Carbonic anhydrase 12
Subcellular Location
Cell membrane; Membrane; Single-pass type I membrane protein
Protein Name
Acid-sensing ion channel 2
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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