Anti-FKBP10 Antibody Picoband®

FK506-binding protein 10 is a protein that in humans is encoded by the FKBP10 gene. The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. This protein localizes to the endoplasmic reticulum and acts as a molecular chaperone. Alternatively spliced variants encoding different isoforms have been reported, but their biological validity has not been determined.

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.

1. Alanay, Y., Avaygan, H., Camacho, N., Utine, G. E., Boduroglu, K., Aktas, D., Alikasifoglu, M., Tuncbilek, E., Orhan, D., Bakar, F. T., Zabel, B., Superti-Furga, A., and 12 others. Mutations in the gene encoding the RER protein FKBP65 cause autosomal-recessive osteogenesis imperfecta. Am. J. Hum. Genet. 86: 551-559, 2010. Note: Erratum: Am. J. Hum. Genet. 87: 572-573, 2010. 2. Alanay, Y., Krakow, D. Response to Shaheen et al. (Letter) Am. J. Hum. Genet. 87: 308 only, 2010. 3. Bank, R. A., Robins, S. P., Wijmenga, C., Breslau-Siderius, L. J., Bardoel, A. F. J., Van der Sluijs, H. A., Pruijs, H. E. H., TeKoppele, J. M. Defective collagen crosslinking in bone, but not in ligament or cartilage, in Bruck syndrome: indications for a bone-specific telopeptide lysyl hydroxylase on chromosome 17. Proc. Nat. Acad. Sci. 96: 1054-1058, 1999.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.