Anti-USP1 Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Ubiquitin carboxyl-terminal hydrolase 1 is an enzyme that in humans is encoded by the USP1 gene. This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized.
Synonyms
Kallikrein-2; Glandular kallikrein-1; hGK-1; Tissue kallikrein-2; KLK2
Gene Name
USP1
Gene ID
7398
UniProt
O94782
Host
Rabbit
Reactivity
Human, Mouse, Monkey
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human USP1 recombinant protein (Position: K73-Y545) .
Clonality
Polyclonal
Applications
Flow Cytometry
Field of Research
Cancer, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
References & Citations
1. Cohn, M. A., Kowal, P., Yang, K., Haas, W., Huang, T. T., Gygi, S. P., D'Andrea, A. D. A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway. Molec. Cell 28: 786-797, 2007. 2. Fujiwara, T., Saito, A., Suzuki, M., Shinomiya, H., Suzuki, T., Takahashi, E., Tanigami, A., Ichiyama, A., Chung, C. H., Nakamura, Y., Tanaka, K. Identification and chromosomal assignment of USP1, a novel gene encoding a human ubiquitin-specific protease. Genomics 54: 155-158, 1998.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Kallikrein-related peptidase 2
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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