Anti-TIMM29 Antibody Picoband® Fluoro488 Conjugated

Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. Required for the stability of the TIM22 complex and functions in the assembly of the TIMM22 protein into the TIM22 complex. May facilitate cooperation between TIM22 and TOM complexes by interacting with TOMM40.

Could induce apoptosis in a BH3 domain-dependent manner. The interaction network of Bcl-2 family members may play a key role in modulation RTL10/BOP intrinsic apoptotic signaling activity.

1. Callegari, S., Richter, F., Chojnacka, K., Jans, D. C., Lorenzi, I., Pacheu-Grau, D., Jakobs, S., Lenz, C., Urlaub, H., Dudek, J., Chacinska, A., Rehling, P. TIM29 is a subunit of the human carrier translocase required for protein transport. FEBS Lett. 590: 4147-4158, 2016. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 02/28/2017. 3. Kang, Y., Baker, M. J., Liem, M., Louber, J., McKenzie, M., Atukorala, I., Ang, C.-S., Keerthikumar, S., Mathivanan, S., Stojanovski, D. Tim29 is a novel subunit of the human TIM22 translocase and is involved in complex assembly and stability. eLife 5: e17463, 2016. Note: Electronic Article.