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Anti-SDS Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Serine dehydratase or L-serine ammonia lyase (SDH) is in the β-family of pyridoxal phosphate-dependent (PLP) enzymes. This gene encodes one of three enzymes that are involved in metabolizing serine and glycine. L-serine dehydratase converts L-serine to pyruvate and ammonia and requires pyridoxal phosphate as a cofactor. The encoded protein can also metabolize threonine to NH4+ and 2-ketobutyrate. The encoded protein is found predominantly in the liver.

Synonyms

Mitochondrial uncoupling protein 2; UCP 2; Solute carrier family 25 member 8; UCPH; UCP2; SLC25A8

Gene Name

SDS

Gene ID

10993

UniProt

P20132

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human SDS recombinant protein (Position: M1-K328) .

Clonality

Polyclonal

Tissue Specificity

Widely expressed in adult human tissues, including tissues rich in macrophages. Most expressed in white adipose tissue and skeletal muscle.

Applications

Flow Cytometry

Field of Research

Cancer, Cancer Metabolism, Energy Transfer Pathways, Integration Of Energy, Integration Of Energy Metabolism, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Obesity, Pathways and Processes

Purification

Immunogen affinity purified.

Form

Liquid

Function

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.

References & Citations

1. Ogawa, H., Gomi, T., Konishi, K., Date, T., Nakashima, H., Nose, K., Matsuda, Y., Peraino, C., Pitot, H. C., Fujioka, M. Human liver serine dehydratase: cDNA cloning and sequence homology with hydroxyamino acid dehydratases from other sources. J. Biol. Chem. 264: 15818-15823, 1989. [PubMed: 2674117, related citations] [Full Ogawa, H., Gomi, T., Konishi, K., Date, T., Nakashima, H., Nose, K., Matsuda, Y., Peraino, C., Pitot, H. C., Fujioka, M. Human liver serine dehydratase: cDNA cloning and sequence homology with hydroxyamino acid dehydratases from other sources. J. Biol. Chem. 264: 15818-15823, 1989.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

33229 MW

Applications Notes

6

Gene Name Synonym

Mitochondrial uncoupling protein 2

Subcellular Location

Mitochondrion inner membrane; Multi-pass membrane protein.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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