Anti-Secretin/Sct Antibody Fluoro488 Conjugated

Secretin is a hormone that regulates water homeostasis throughout the body and influences the environment of the duodenum by regulating secretions in the stomach, pancreas, and liver. It is a peptide hormone produced in the S cells of the duodenum, which are located in the intestinal glands. In humans, the secretin peptide is encoded by the SCT gene. This gene encodes the precursor of a gastrointestinal peptide hormone of the secretin-glucagon family. The encoded protein is secreted as a prohormone that undergoes proteolytic processing to generate a mature peptide hormone. The mature peptide regulates secretion of gastric acid, biocarbonate ions from pancreatic and biliary duct epithelia and water homeostasis in the gastrointestinal system. Mice lacking the encoded protein display decreased survival of neuroprogenitor cells during early postnatal period and impaired long-term potentiation and spatial learning in adulthood. Alternative splicing results in multiple transcript variants encoding different isoforms. All of these isoforms may be processed in a similar manner to generate the mature peptide hormone.

1. Bayliss, W., Starling, E. H. The mechanism of pancreatic secretion. J. Physiol. (London) 28: 325-353, 1902. 2. Chu, J. Y. S., Chung, S. C. K., Lam, A. K. M., Tam, S., Chung, S. K., Chow, B. K. C. Phenotypes developed in secretin receptor-null mice indicated a role for secretin in regulating renal water reabsorption. Molec. Cell Biol. 27: 2499-2511, 2007. 3. Chu, J. Y. S., Lee, L. T. O., Lai, C. H., Vaudry, H., Chan, Y. S., Yung, W. H., Chow, B. K. C. Secretin as a neurohypophysial factor regulating body water homeostasis. Proc. Nat. Acad. Sci. 106: 15961-15966, 2009.