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Anti-PPIL3 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Peptidyl-prolyl cis-trans isomerase-like 3 is an enzyme that in humans is encoded by the PPIL3 gene. This gene encodes a member of the cyclophilin family. Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. They have been proposed to act either as catalysts or as molecular chaperones in protein-folding events. Alternative splicing results in multiple transcript variants.

Synonyms

Nck-associated protein 1; NAP 1; Membrane-associated protein HEM-2; p125Nap1; NCKAP1; HEM2, KIAA0587, NAP1

Gene Name

PPIL3

Gene ID

53938

UniProt

Q9H2H8

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human PPIL3 recombinant protein (Position: M1-Q161) .

Clonality

Polyclonal

Tissue Specificity

Expressed in all tissues examined except peripheral blood leukocytes, with highest expression in brain, heart, and skeletal muscle.

Applications

Flow Cytometry

Field of Research

Neurogenesis, Neurology Process, Neuroscience, NFKB Pathway, Nuclear Signaling, Signal Transduction, Signaling Pathway

Purification

Immunogen affinity purified.

Form

Liquid

Function

Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1.

References & Citations

1. Zhou, Z., Ying, K., Dai, J., Tang, R., Wang, W., Huang, Y., Zhao, W., Xie, Y., Mao, Y. Molecular cloning and characterization of a novel peptidylprolyl isomerase (cyclophilin) -like gene (PPIL3) from human fetal brain. Cytogenet. Cell Genet. 92: 231-236, 2001.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

128790 MW

Applications Notes

6

Gene Name Synonym

Nck-associated protein 1

Subcellular Location

Cell membrane ; Single-pass membrane protein ; Cytoplasmic side . Cell projection, lamellipodium membrane ; Single-pass membrane protein ; Cytoplasmic side . At the interface between the lamellipodial actin meshwork and the membrane. .

Protein Name

Nck-associated protein 1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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