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Anti-PITRM1 Antibody Picoband® Fluoro550 Conjugated

Selected Variant

A08969-1-Fluoro550

Size: 100 µg/Vial

Product Specifications

Background

Pitrilysin metallopeptidase 1 also known as presequence protease, mitochondrial (PreP) and metalloprotease 1 (MTP-1) is an enzyme that in humans is encoded by the PITRM1 gene. The protein encoded by this gene is an ATP-dependent metalloprotease that degrades post-cleavage mitochondrial transit peptides. The encoded protein binds zinc and can also degrade amyloid beta A4 protein, suggesting a possible role in Alzheimer's disease.

Synonyms

Immunoglobulin lambda-like polypeptide 1; CD179 antigen-like family member B; Ig lambda-5; Immunoglobulin omega polypeptide; Immunoglobulin-related protein 14.1; CD179b; IGLL1; IGL1

Gene Name

PITRM1

Gene ID

10531

UniProt

Q5JRX3

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human PITRM1 recombinant protein (Position: A33-K1037) .

Clonality

Polyclonal

Tissue Specificity

Expressed only in pre-B-cells and a special B-cell line (which is surface Ig negative) .

Applications

Flow Cytometry

Field of Research

Adaptive Immunity, B Cells, Immunoglobulins, Immunology

Purification

Immunogen affinity purified.

Form

Liquid

Function

Critical for B-cell development.

References & Citations

1. Falkevall, A., Alikhani, N., Bhushan, S., Pavlov, P. F., Busch, K., Johnson, K. A., Eneqvist, T., Tjernberg, L., Ankarcrona, M., Glaser, E. Degradation of the amyloid beta-protein by the novel mitochondrial peptidasome, PreP. J. Biol. Chem. 281: 29096-29104, 2006. 2. Mzhavia, N., Berman, Y. L., Qian, Y., Yan, L., Devi, L. A. Cloning, expression, and characterization of human metalloprotease 1: a novel member of the pitrilysin family of metalloendoproteases. DNA Cell Biol. 18: 369-380, 1999. 3. Teixeira, P. F., Pinho, C. M., Branca, R. M., Lehtio, J., Levine, R. L., Glaser, E. In vitro oxidative inactivation of human presequence protease (hPreP) . Free Radic. Biol. Med. 53: 2188-2195, 2012.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

117 kDa

Applications Notes

6

Gene Name Synonym

Immunoglobulin lambda like polypeptide 1

Subcellular Location

Secreted.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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