Anti-PAR-3/PARD3 Antibody Picoband® Fluoro594 Conjugated
Product Specifications
Background
Partitioning defective 3 homolog is a protein that in humans is encoded by the PARD3 gene. This gene encodes a member of the PARD protein family. PARD family members interact with other PARD family members and other proteins; they affect asymmetrical cell division and polarized cell growth. Multiple alternatively spliced transcript variants have been described for this gene.
Synonyms
C-C chemokine receptor type 1; C-C CKR-1; CC-CKR-1; CCR-1; CCR1; Macrophage inflammatory protein 1-alpha receptor; MIP-1alpha-R; RANTES-R; CD191; Ccr1; Cmkbr1
Gene Name
PARD3
Gene ID
56288
UniProt
Q8TEW0
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human PAR-3/PARD3 recombinant protein (Position: M1-Q1346) .
Clonality
Polyclonal
Tissue Specificity
Detected in the heart, spleen, lung, peritoneal exudate cells and leukocytes.
Applications
Flow Cytometry
Field of Research
Chemokines, Immunology, Innate Immunity
Purification
Immunogen affinity purified.
Form
Liquid
Function
Receptor for a C-C type chemokine. Binds to MIP-1-alpha, RANTES, and less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.
References & Citations
1. Chan, J. R., Jolicoeur, C., Yamauchi, J., Elliott, J., Fawcett, J. P., Ng, B. K., Cayouette, M. The polarity protein Par-3 ly interacts with p75 (NTR) to regulate myelination. Science 314: 832-836, 2006. 2. Chen, X., An, Y., Gao, Y., Guo, L., Rui, L., Xie, H., Sun, M., Lam Hung, S., Sheng, X., Zou, J., Bao, Y., Guan, H., Niu, B., Li, Z., Finnell, R. H., Gusella, J. F., Wu, B.-L., Zhang, T. Rare deleterious PARD3 variants in the aPKC-binding region are implicated in the pathogenesis of human cranial neural tube defects via disrupting apical tight junction formation. Hum. Mutat. 38: 378-389, 2017. 3. Coureuil, M., Mikaty, G., Miller, F., Lecuyer, H., Bernard, C., Bourdoulous, S., Dumenil, G., Mege, R.-M., Weksler, B. B., Romero, I. A., Couraud, P.-O., Nassif, X. Meningococcal type IV pili recruit the polarity complex to cross the brain endothelium. Science 325: 83-87, 2009.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
40895 MW
Applications Notes
6
Gene Name Synonym
C-C chemokine receptor type 1
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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