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Anti-NDUFAF1 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Complex I intermediate-associated protein 30, mitochondrial (CIA30) is a protein that in humans is encoded by the NDUFAF1 gene. This gene encodes a complex I assembly factor protein. Complex I (NADH-ubiquinone oxidoreductase) catalyzes the transfer of electrons from NADH to ubiquinone (coenzyme Q) in the first step of the mitochondrial respiratory chain, resulting in the translocation of protons across the inner mitochondrial membrane. The encoded protein is required for assembly of complex I, and mutations in this gene are a cause of mitochondrial complex I deficiency. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 19.

Synonyms

Protein NDRG3; N-myc downstream-regulated gene 3 protein; NDRG3

Gene Name

NDUFAF1

Gene ID

51103

UniProt

Q9Y375

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human NDUFAF1 recombinant protein (Position: D79-K327) .

Clonality

Polyclonal

Tissue Specificity

Ubiquitous. Highly expressed in brain. .

Applications

Flow Cytometry

Field of Research

Cancer, Cell Biology, Cell Cycle, Cell Differentiation, Tumor Biomarkers

Purification

Immunogen affinity purified.

Form

Liquid

Function

Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases.

References & Citations

1. Dunning, C. J. R., McKenzie, M., Sugiana, C., Lazarou, M., Silke, J., Connelly, A., Fletcher, J. M., Kirby, D. M., Thorburn, D. R., Ryan, M. T. Human CIA30 is involved in the early assembly of mitochondrial complex I and mutations in its gene cause disease. EMBO J. 26: 3227-3237, 2007. 2. Fassone, E., Taanman, J.-W., Hargreaves, I. P., Sebire, N. J., Cleary, M. A., Burch, M., Rahman, S. Mutations in the mitochondrial complex I assembly factor NDUFAF1 cause fatal infantile hypertrophic cardiomyopathy. J. Med. Genet. 48: 691-697, 2011. 3. Janssen, R., Smeitink, J., Smeets, R., van den Heuvel, L. CIA30 complex I assembly factor: a candidate for human complex I deficiency? Hum. Genet. 110: 264-270, 2002.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

41409 MW

Applications Notes

6

Gene Name Synonym

Protein NDRG3

Subcellular Location

Membrane ; Single-pass type I membrane protein .

Protein Name

Protein NDRG3

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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