Anti-KLHL12 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Kelch-like protein 12 is a protein that in humans is encoded by the KLHL12 gene. This gene encodes a member of the KLHL (Kelch-like) family of proteins. This protein has been identified as an autoantigen in the autoimmune disease Sjogren's syndrome and as a potential biomarker in primary biliary cirrhosis. This protein may act as a substrate adaptor of the Cullin-3 ubiquitin ligase complex to promote substrate-specific ubiquitylation. Ubiquitylation by this complex has been shown to regulate the Wnt signaling pathway as well as COPII vesicle coat size. A pseudogene has been identified on chromosome 22. Alternative splicing results in multiple transcript variants.
Synonyms
Gap junction gamma-1 protein; Connexin-45; Cx45; Gap junction alpha-7 protein; GJC1; GJA7
Gene Name
KLHL12
Gene ID
59349
UniProt
Q53G59
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E.coli-derived human KLHL12 recombinant protein (Position: R27-I331) .
Clonality
Polyclonal
Tissue Specificity
Ubiquitously expressed.
Applications
Flow Cytometry
Field of Research
Cell Adhesion, Cytoskeleton/ECM, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
References & Citations
1. Hartz, P. A. Personal Communication. Baltimore, Md. 3/7/2012. 2. Jin, L., Pahuja, K. B., Wickliffe, K. E., Gorur, A., Baumgartel, C., Schekman, R., Rape, M. Ubiquitin-dependent regulation of COPII coat size and function. Nature 482: 495-500, 2012. 3. Mai, A., Jung, S.-K., Yonehara, S. hDKIR, a human homologue of the Drosophila kelch protein, involved in a ring-like structure. Exp. Cell Res. 300: 72-83, 2004.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
45470 MW
Applications Notes
6
Gene Name Synonym
Gap junction gamma-1 protein
Subcellular Location
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Protein Name
Gap junction gamma-1 protein
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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