Anti-IFIT5 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
IFIT5, also named as Interferon-induced 58 kDa protein or RI58, is a 482 amino acid protein, which contains eight TPR repeats and belongs to the IFIT family. IFIT5 localizes in the Cell projection. Interferon-induced RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs.
Synonyms
BAG family molecular chaperone regulator 5; BAG-5; Bcl-2-associated athanogene 5; BAG5; KIAA0873
Gene Name
IFIT5
Gene ID
24138
UniProt
Q13325
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human IFIT5 recombinant protein (Position: N23-S439) .
Clonality
Polyclonal
Tissue Specificity
Expressed in all tissues examined with lower levels in brain and testis.
Applications
Flow Cytometry
Field of Research
Interleukins
Purification
Immunogen affinity purified.
Form
Liquid
Function
Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity) . May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. .
References & Citations
1. Abbas, Y. M., Pichlmair, A., Gorna, M. W., Superti-Furga, G., Nagar, B. Structural basis for viral 5-prime-PPP-RNA recognition by human IFIT proteins. Nature 494: 60-64, 2013. 2. Feng, F., Yuan, L., Wang, Y. E., Crowley, C., Lv, Z., Li, J., Liu, Y., Cheng, G., Zeng, S., Liang, H. Crystal structure and nucleotide selectivity of human IFIT5/ISG58. (Letter) Cell Res. 23: 1055-1058, 2013. 3. Gross, M. B. Personal Communication. Baltimore, Md. 12/18/2014.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
51200 MW
Applications Notes
6
Gene Name Synonym
BAG family molecular chaperone regulator 5
Subcellular Location
Perinuclear region.
Protein Name
BAG family molecular chaperone regulator 5
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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