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Anti-Id1 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

DNA-binding protein inhibitor ID-1 is a protein that in humans is encoded by the ID1 gene. The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene.

Synonyms

T-cell acute lymphocytic leukemia protein 1; TAL-1; Class A basic helix-loop-helix protein 17; bHLHa17; Stem cell protein; T-cell leukemia/lymphoma protein 5; TAL1; BHLHA17; SCL; TCL5

Gene Name

Id1

Gene ID

15901

UniProt

P20067

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived mouse Id1 recombinant protein (Position: C16-I168) .

Clonality

Polyclonal

Tissue Specificity

Leukemic stem cell.

Applications

Flow Cytometry

Field of Research

Cell Differentiation, Developmental Biology, Epigenetics and Nuclear Signaling, Hematopoietic Progenitors, Organogenesis, Stem Cells

Purification

Immunogen affinity purified.

Form

Liquid

Function

Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity) .

References & Citations

1. Ding, B.-S., Cao, Z., Lis, R., Nolan, D. J., Guo, P., Simons, M., Penfold, M. E., Shido, K., Rabbany, S. Y., Rafii, S. Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis. Nature 505: 97-102, 2014. 2. Ding, B.-S., Nolan, D. J., Butler, J. M., James, D., Babazadeh, A. O., Rosenwaks, Z., Mittal, V., Kobayashi, H., Shido, K., Lyden, D., Sato, T. N., Rabbany, S. Y., Rafii, S. Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration. Nature 468: 310-315, 2010. 3. Fraidenraich, D., Stillwell, E., Romero, E., Wilkes, D., Manova, K., Basson, C. T., Benezra, R. Rescue of cardiac defects in Id knockout embryos by injection of embryonic stem cells. Science 306: 247-252, 2004.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

50408 MW

Applications Notes

6

Gene Name Synonym

TAL bHLH transcription factor 1, erythroid differentiation factor

Subcellular Location

Nucleus.

Protein Name

Protein C-ets-1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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