Anti-HECTD1 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
HECTD1 (E3 ubiquitin-protein ligase), which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then ly transfers the ubiquitin to targeted substrates, may be required for development of the head mesenchyme and neural tube closure.It is also involved in sporadic Parkinson's disease (PMID:16714300) .This protein is specific to HECTD1.
Synonyms
Kallistatin; Kallikrein inhibitor; Peptidase inhibitor 4; PI-4; Serpin A4; SERPINA4; KST; PI4
Gene Name
HECTD1
Gene ID
25831
UniProt
Q9ULT8
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human HECTD1 recombinant protein (Position: D39-S566) .
Clonality
Polyclonal
Tissue Specificity
Expressed by the liver and secreted in plasma.
Applications
Flow Cytometry
Field of Research
Cancer, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Metalloprotease, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein.
References & Citations
1. Aleidi, S. M., Yang, A., Sharpe, L. J., Rao, G., Cochran, B. J., Rye, K.-A., Kockx, M., Brown, A. J., Gelissen, I. C. The E3 ubiquitin ligase, HECTD1, is involved in ABCA1-mediated cholesterol export from macrophages. Biochim. Biophys. Acta Molec. Cell Biol. Lipids 1863: 359-368, 2018. 2. D'Alonzo, D., Emch, F. H., Shen, X., Bruder, E., De Geyter, C., Zhang, H. Hectd1 is essential for embryogenesis in mice. Gene Expr. Patterns 34: 119064, 2019. Note: Electronic Article. 3. Gross, M. B. Personal Communication. Baltimore, Md. 10/29/2019.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
82457 MW
Applications Notes
6
Gene Name Synonym
Serpin family A member 4
Subcellular Location
Secreted.
Protein Name
Disintegrin and metalloproteinase domain-containing protein 2
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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