Anti-Granzyme M/GZMM Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Granzyme M is a protein that in humans is encoded by the GZMM gene. Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms
Neuropeptides B/W receptor type 1; G-protein coupled receptor 7; NPBWR1; GPR7
Gene Name
Gzmm
Gene ID
16904
UniProt
O08643
Host
Rabbit
Reactivity
Mouse
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived mouse Granzyme M/GZMM recombinant protein (Position: A64-D206) .
Clonality
Polyclonal
Tissue Specificity
Found in cerebellum and frontal cortex. Detected at high levels in hippocampus, amygdala and trachea; at moderate levels in fetal brain, pituitary gland and prostate. Not in caudate, accumbens, kidney or liver. Also detected at high levels in lung carcinoma.
Applications
Flow Cytometry
Field of Research
Immune System Diseases, Immunology, Protein Trafficking, Signal Transduction, Signaling Pathway
Purification
Immunogen affinity purified.
Form
Liquid
Function
Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. Has a higher affinity for neuropeptide B.
References & Citations
1. Pao, L. I., Sumaria, N., Kelly, J. M., van Dommelen, S., Cretney, E., Wallace, M. E., Anthony, D. A., Uldrich, A. P., Godfrey, D. I., Papadimitriou, J. M., Mullbacher, A., Degli-Esposti, M. A., Smyth, M. J. Functional analysis of granzyme M and its role in immunity to infection. J. Immun. 175: 3235-3243, 2005. 2. Pilat, D., Fink, T., Obermaier-Skrobanek, B., Zimmer, M., Wekerle, H., Lichter, P., Jenne, D. E. The human Met-ase gene (GZMM) : structure, sequence, and close physical linkage to the serine protease gene cluster on 19p13.3. Genomics 24: 445-450, 1994.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Neuropeptides B and W receptor 1
Subcellular Location
Cell membrane. Multi-pass membrane protein.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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