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Anti-Fibulin 1/FBLN1 Antibody Picoband®

Boster Bio Anti-Fibulin 1/FBLN1 Antibody Picoband® catalog # A02970-1. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

FBLN1 is the gene encoding fibulin-1, an extracellular matrix and plasma protein. Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3' end have been identified. Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants.

Synonyms

Insulin gene enhancer protein ISL-1; Islet-1; ISL1

Gene Name

FBLN1

Gene ID

2192

UniProt

P23142

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human Fibulin 1/FBLN1 recombinant protein (Position: D30-F703) .

Clonality

Polyclonal

Tissue Specificity

Expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain.

Applications

WB, ICC, IF, Flow Cytometry, ELISA

Field of Research

Atherosclerosis, Cardiogenesis, Cardiovascular, Cell Type Marker, Developmental Biology, Diabetes-associated, Intracellular, Lineage Markers, Lineage Specification, Neural Stem Cells, Neurogenesis, Neurology Process, Neuron Marker, Neuroscience, Organogenesis, Stem Cells, Transcription Factors/Regulators

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Function

Binds and regulates the promoters of the insulin, glucagon and somatostatin genes. Involved in the specificarion of motor neurons in cooperation with LHX3 and LDB1 (By similarity) . .

References & Citations

1. Argraves, W. S., Dickerson, K., Burgess, W. H., Ruoslahti, E. Fibulin, a novel protein that interacts with the fibronectin receptor-beta subunit cytoplasmic domain. Cell 58: 623-629, 1989. 2. Argraves, W. S., Tran, H., Burgess, W. H., Dickerson, K. Fibulin is an extracellular matrix and plasma glycoprotein with repeated domain structure. J. Cell Biol. 111: 3155-3164, 1990. 3. Bohlega, S., Al-Ajlan, H., Al-Saif, A. Mutation of fibulin-1 causes a novel syndrome involving the central nervous system and connective tissues. Europ. J. Hum. Genet. 22: 640-643, 2014.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

39036 MW

Observed Molecular Weight

90 kDa

Applications Notes

6

Gene Name Synonym

Insulin gene enhancer protein ISL-1

Subcellular Location

Nucleus.

Protein Name

Insulin gene enhancer protein ISL-1

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

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