Anti-ELL Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
RNA polymerase II elongation factor ELL is an enzyme that in humans is encoded by the ELL gene. Eleven-nineteen lysine-rich leukemia protein (ELL) was originally identified in a screen for genes that fuse to MLL (myeloid-lymphoid leukemia) in the t (11;19) (q23; p13.1) breakpoint. ELL is an elongation factor that increases the catalytic rate of RNA pol II by suppressing transient pausing of RNA pol II. ELL has been shown to be essential to development and important to cell growth and survival. Alternate names for ELL include RNA polymerase II elongation factor ELL, ELL1, and men.
Synonyms
Glutathione S-transferase Mu 3; GST class-mu 3; GSTM3-3; hGSTM3-3; GSTM3; GST5
Gene Name
ELL
Gene ID
8178
UniProt
P55199
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human ELL recombinant protein (Position: M1-S407) .
Clonality
Polyclonal
Tissue Specificity
Testis and brain.
Applications
Flow Cytometry
Field of Research
Cancer, Drug Metabolism, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers.
References & Citations
1. Lavau, C., Luo, R. T., Du, C., Thirman, M. J. Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice. Proc. Nat. Acad. Sci. 97: 10984-10989, 2000. 2. Shilatifard, A., Lane, W. S., Jackson, K. W., Conaway, R. C., Conaway, J. W. An RNA polymerase II elongation factor encoded by the human ELL gene. Science 271: 1873-1876, 1996. 3. Thirman, M. J., Levitan, D. A., Kobayashi, H., Simon, M. C., Rowley, J. D. Cloning of ELL, a gene that fuses to MLL in a t (11;19) (q23; p13.1) in acute myeloid leukemia. Proc. Nat. Acad. Sci. 91: 12110-12114, 1994.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Glutathione S-transferase mu 3
Subcellular Location
Cytoplasm.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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