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Anti-CPT1B Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

CPT1B is located on 22q13.33. The protein encoded by this gene, a member of the carnitine/ choline acetyltransferase family, is the rate-controlling enzyme of the long-chain fatty acid beta-oxidation pathway in muscle mitochondria. This enzyme is required for the net transport of long-chain fatty acyl-CoAs from the cytoplasm into the mitochondria. Multiple transcript variants encoding different isoforms have been found for this gene, and read-through transcripts are expressed from the upstream locus that include exons from this gene.

Synonyms

Non-homologous end-joining factor 1; Protein cernunnos; XRCC4-like factor; NHEJ1; XLF

Gene Name

CPT1B

Gene ID

1375

UniProt

Q92523

Host

Rabbit

Reactivity

Human, Mouse, Rat, Monkey

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human CPT1B recombinant protein (Position: R180-S772) .

Clonality

Polyclonal

Tissue Specificity

Widely expressed.

Applications

Flow Cytometry

Field of Research

Cell Biology, Cell Type Markers, Developmental Biology, Reproduction, Tags & Cell Markers

Purification

Immunogen affinity purified.

Form

Liquid

Function

DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V (D) J recombination. May serve as a bridge between XRCC4 and the other NHEJ factors located at DNA ends, or may participate in reconfiguration of the end bound NHEJ factors to allow XRCC4 access to the DNA termini. It may act in concert with XRCC6/XRCC5 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are noncomplementary or partially complementary. Binds DNA in a length-dependent manner.

References & Citations

1. Auinger A; Rubin D; Sabandal M; Helwig U; Rüther A; Schreiber S; Foelsch UR; Döring F; Schrezenmeir J. “A common haplotype of carnitine palmitoyltransferase 1b is associated with the metabolic syndrome”. Br J Nutr, 2013 Mar 14.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

75187 MW

Applications Notes

6

Gene Name Synonym

Non-homologous end joining factor 1

Subcellular Location

Nucleus.

Protein Name

Segment polarity protein dishevelled homolog DVL-1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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