Anti-CLPP Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
ATP-dependent Clp protease proteolytic subunit (ClpP) is an enzyme that in humans is encoded by the CLPP gene. It is mapped to 19p13.3. The protein encoded by this gene belongs to the peptidase family S14 and hydrolyzes proteins into small peptides in the presence of ATP and magnesium. The protein is transported into mitochondrial matrix and is associated with the inner mitochondrial membrane.
Synonyms
ATP-dependent Clp protease proteolytic subunit, mitochondrial; Endopeptidase Clp; CLPP
Gene Name
CLPP
Gene ID
8192
UniProt
Q16740
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human CLPP recombinant protein (Position: P57-E262) .
Clonality
Polyclonal
Tissue Specificity
Detected in liver (at protein level) . Predominantly expressed in skeletal muscle. Intermediate levels in heart, liver and pancreas. Low in brain, placenta, lung and kidney.
Applications
Flow Cytometry
Field of Research
Cancer, Metabolism, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Pathways and Processes, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates.
References & Citations
1. Entrez Gene: CLPP ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli) . 2. Bross P, Andresen BS, Knudsen I, Kruse TA, Gregersen N (Feb 1996) . Human ClpP protease: cDNA sequence, tissue-specific expression and chromosomal assignment of the gene. FEBS Lett. 377 (2) : 249–52. 3. Corydon, TJ; Bross, P; Holst, HU; Neve, S; Kristiansen, K; Gregersen, N; Bolund, L (1 April 1998) . A human homologue of Escherichia coli ClpP caseinolytic protease: recombinant expression, intracellular processing and subcellular localization.. The Biochemical Journal. 331 (1) : 309–16.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Caseinolytic mitochondrial matrix peptidase proteolytic subunit
Subcellular Location
Mitochondrion matrix.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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