Anti-ACF1/BAZ1A Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Bromodomain adjacent to zinc finger domain protein 1A is a protein that in humans is encoded by the BAZ1A gene. The BAZ1A gene encodes the accessory subunit of the ATP-dependent chromatin assembly factor (ACF), a member of the ISWI ('imitation switch') family of chromatin remodeling complexes.
Synonyms
Muscarinic acetylcholine receptor M1; CHRM1
Gene Name
BAZ1A
Gene ID
11177
UniProt
Q9NRL2
Host
Rabbit
Reactivity
Human, Mouse, Rat, Monkey
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human ACF1/BAZ1A recombinant protein (Position: E1033-H1536) .
Clonality
Polyclonal
Tissue Specificity
Sperm. Mainly localized in the tail and in the postacrosomal region but is also found in the midpiece and basal region in a small percentage of sperm cells. Reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level) . Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes.
Applications
Flow Cytometry
Field of Research
Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
References & Citations
1. Blosser, T. R., Yang, J. G., Stone, M. D., Narlikar, G. J., Zhuang, X. Dynamics of nucleosome remodelling by individual ACF complexes. Nature 462: 1022-1027, 2009. 2. Bochar, D. A., Savard, J., Wang, W., Lafleur, D. W., Moore, P., Cote, J., Shiekhattar, R. A family of chromatin remodeling factors related to Williams syndrome transcription factor. Proc. Nat. Acad. Sci. 97: 1038-1043, 2000. 3. Collins, N., Poot, R. A., Kukimoto, I., Garcia-Jimenez, C., Dellaire, G., Varga-Weisz, P. D. An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin. Nature Genet. 32: 627-632, 2002.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
211344 MW
Applications Notes
6
Gene Name Synonym
Cholinergic receptor muscarinic 1
Subcellular Location
Cell membrane. Multi-pass membrane protein. Postsynaptic cell membrane. Multi-pass membrane protein.
Protein Name
Chromodomain-helicase-DNA-binding protein 2
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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