Anti-ASF1B Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Histone chaperone ASF1B is a protein that in humans is encoded by the ASF1B gene. This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may play a key role in modulating the nucleosome structure of chromatin by ensuring a constant supply of histones at sites of nucleosome assembly.
Synonyms
Mucin-7; MUC-7; Apo-MG2; Salivary mucin-7; MUC7; MG2
Gene Name
ASF1B
Gene ID
55723
UniProt
Q9NVP2
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human ASF1B recombinant protein (Position: M1-I202) .
Clonality
Polyclonal
Tissue Specificity
Expressed in salivary gland tissues and only in those that contain mucous acinar cells (e.g. sublingual and submandibular glands) and not in salivary glands containing only serous acinar cells (e.g. parotid gland) .
Applications
Flow Cytometry
Field of Research
Cancer, Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Immunology, Invasion/Microenvironment, Secreted Molecules, Signal Transduction, Tumor Biomarkers
Purification
Immunogen affinity purified.
Form
Liquid
Function
May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili.
References & Citations
1. Groth, A., Corpet, A., Cook, A. J. L., Roche, D., Bartek, J., Lukas, J., Almouzni, G. Regulation of replication fork progression through histone supply and demand. Science 318: 1928-1931, 2007. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 2/3/2005. 3. Mello, J. A., Sillje, H. H. W., Roche, D. M. J., Kirschner, D. B., Nigg, E. A., Almouzni, G. Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway. EMBO Rep. 3: 329-334, 2002.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
39411 MW
Applications Notes
6
Gene Name Synonym
Mucin 7, secreted
Subcellular Location
Secreted.
Protein Name
Long-chain-fatty-acid--CoA ligase 5
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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