Anti-ADRM1/ARM-1 Antibody Picoband® Fluoro594 Conjugated
Product Specifications
Background
Proteasomal ubiquitin receptor ADRM1 is a protein that in humans is encoded by the ADRM1 gene. This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an in effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants.
Synonyms
Ran-specific GTPase-activating protein; Ran-binding protein 1; RanBP1; RANBP1
Gene Name
ADRM1
Gene ID
11047
UniProt
Q16186
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human ADRM1/ARM-1 recombinant protein (Position: S15-K390) .
Clonality
Polyclonal
Tissue Specificity
Ubiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart, kidney, liver, lung, pancreas, prostate and spleen. In the kidney, it is widely expressed in tubules, but sparsely expressed in the glomerulus (PubMed:24676636) . Expression is significantly increased in renal biopsy specimens from idiopathic FSGS (PubMed:24676636) . Overexpressed in many tumor types including breast, colorectal, endometrial, hepatic, kidney, lung, ovarian and pancreatic tumors.
Applications
Flow Cytometry
Field of Research
Cell Biology, Cell Cycle, Cell Division, DNA/RNA, Epigenetics and Nuclear Signaling, Nuclear Import/Export, Protein Trafficking, RNA Processing, Signal Transduction, Spindle
Purification
Immunogen affinity purified.
Form
Liquid
Function
Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane.
References & Citations
1. Husnjak, K., Elsasser, S., Zhang, N., Chen, X., Randles, L., Shi, Y., Hofmann, K., Walters, K. J., Finley, D., Dikic, I. Proteasome subunit Rpn13 is a novel ubiquitin receptor. Nature 453: 481-488, 2008. 2. Jorgensen, J. P., Lauridsen, A.-M., Kristensen, P., Dissing, K., Johnsen, A. H., Hendil, K. B., Hartmann-Petersen, R. Adrm1, a putative cell adhesion regulating protein, is a novel proteasome-associated factor. J. Molec. Biol. 360: 1043-1052, 2006. 3. Lamerant, N., Kieda, C. Adhesion properties of adhesion-regulating molecule 1 protein on endothelial cells. FEBS J. 272: 1833-1844, 2005.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=A04010-2-Fluoro594
Calculated Molecular Weight
23310 MW
Applications Notes
6
Gene Name Synonym
Ran-specific GTPase-activating protein
Subcellular Location
Cytoskeleton. Nucleus. Cell cortex. Bleb.
Protein Name
Ran-specific GTPase-activating protein
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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