Anti-Sox11 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Transcription factor SOX-11 is a protein that in humans is encoded by the SOX11 gene. This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis.
Synonyms
Nuclear factor of activated T-cells, cytoplasmic 4; NF-ATc4; NFATc4; T-cell transcription factor NFAT3; NF-AT3; NFATC4; NFAT3
Gene Name
Sox11
Gene ID
20666
UniProt
Q7M6Y2
Host
Rabbit
Reactivity
Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived mouse Sox11 recombinant protein (Position: M1-E358) .
Clonality
Polyclonal
Tissue Specificity
Highly expressed in placenta, lung, kidney, testis and ovary. Weakly expressed in spleen and thymus. Not expressed in peripheral blood lymphocytes. Detected in hippocampus.
Applications
Flow Cytometry
Field of Research
Adaptive Immunity, Epigenetics and Nuclear Signaling, Immunology, Non-CD, Nuclear Signaling, Nuclear Signaling Pathways, Signal Transduction, Signaling Pathway, T Cells, Transcription
Purification
Immunogen affinity purified.
Form
Liquid
Function
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL- 4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons.
References & Citations
1. Dodonova, S. O., Zhu, F., Dienemann, C., Taipale, J., Cramer, P. Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function. Nature 580: 669-672, 2020. 2. Jay, P., Goze, C., Marsollier, C., Taviaux, S., Hardelin, J.-P., Koopman, P., Berta, P. The human SOX11 gene: cloning, chromosomal assignment and tissue expression. Genomics 29: 541-545, 1995. 3. Laudet, V., Stehelin, D., Clevers, H. Ancestry and diversity of the HMG box superfamily. Nucleic Acids Res. 21: 2493-2501, 1993.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Nuclear factor of activated T-cells 4
Subcellular Location
Cytoplasm
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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