Anti-SLC5A8 Antibody Picoband® Fluoro488 Conjugated

Sodium-coupled monocarboxylate transporter 1 is a protein that in humans is encoded by the SLC5A8 gene. SLC5A8 has been shown to transport iodide by a passive mechanism and monocarboxylates and short-chain fatty acids by a sodium-coupled mechanism. In kidney, SLC5A8 functions as a high-affinity sodium-coupled lactate transporter involved in reabsorption of lactate and maintenance of blood lactate levels.

Cancer, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction

1. Babu, E., Ramachandran, S., CoothanKandaswamy, V., Elangovan, S., Prasad, P. D., Ganapathy, V., Thangaraju, M. Role of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate. Oncogene 30: 4026-4037, 2011. 2. Gopal, E., Fei, Y.-J., Sugawara, M., Miyauchi, S., Zhuang, L., Martin, P., Smith, S. B., Prasad, P. D., Ganapathy, V. Expression of slc5a8 in kidney and its role in Na (+) -coupled transport of lactate. J. Biol. Chem. 279: 44522-44532, 2004. 3. Li, H., Myeroff, L., Smiraglia, D., Romero, M. F., Pretlow, T. P., Kasturi, L., Lutterbaugh, J., Rerko, R. M., Casey, G., Issa, J.-P., Willis, J., Willson, J. K. V., Plass, C., Markowitz, S. D. SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers. Proc. Nat. Acad. Sci. 100: 8412-8417, 2003.