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Anti-P2X7/P2RX7 Antibody Picoband® Fluoro647 Conjugated

Selected Variant

A01208-3-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

P2X purinoceptor 7 is a protein that in humans is encoded by the P2RX7 gene. The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria.

Synonyms

Vinculin; Metavinculin; MV; VCL

Gene Name

P2RX7

Gene ID

5027

UniProt

Q99572

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human P2X7/P2RX7 recombinant protein (Position: S47-K311) .

Clonality

Polyclonal

Tissue Specificity

Metavinculin is muscle-specific.

Applications

Flow Cytometry

Field of Research

Actin Binding Proteins, Actin, etc., Cardiovascular, Contractility, Cytoskeleton, Cytoskeleton/ECM, Microfilaments, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Actin filament (F-actin) -binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.

References & Citations

1. Adriouch, S., Dox, C., Welge, V., Seman, M., Koch-Nolte, F., Haag, F. Cutting edge: a natural P451L mutation in the cytoplasmic domain impairs the function of the mouse P2X7 receptor. J. Immun. 169: 4108-4112, 2002. 2. Atkinson, L., Milligan, C. J., Buckley, N. J., Deuchars, J. An ATP-gated ion channel at the cell nucleus. Nature 420: 42 only, 2002. 3. Borges da Silva, H., Beura, L. K., Wang, H., Hanse, E. A., Gore, R., Scott, M. C., Walsh, D. A., Block, K. E., Fonseca, R., Yan, Y., Hippen, K. L., Blazar, B. R., Masopust, D., Kelekar, A., Vulchanova, L., Hogquist, K. A., Jameson, S. C. The purinergic receptor P2RX7 s metabolic fitness of long-lived memory CD8+ T cells. Nature 559: 264-268, 2018.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

123799 MW

Applications Notes

6

Gene Name Synonym

Vinculin

Subcellular Location

Cell membrane. Peripheral membrane protein. Cytoplasmic side. Sarcolemma. Cytoskeleton. Adherens junction. Focal adhesion.

Protein Name

Vinculin

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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