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Anti-5HT1B/HTR1B Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

5-hydroxytryptamine receptor 1B also known as the 5-HT1B receptor is a protein that in humans is encoded by the HTR1B gene. The protein encoded by this intronless gene is a G-protein coupled receptor for serotonin (5-hydroxytryptamine) . Ligand binding activates second messengers that inhibit the activity of adenylate cyclase and manage the release of serotonin, dopamine, and acetylcholine in the brain. The encoded protein may be involved in several neuropsychiatric disorders and therefore is often a target of antidepressant and other psychotherapeutic drugs.

Synonyms

Thy-1 membrane glycoprotein; CDw90; Thy-1 antigen; CD90; THY1

Gene Name

HTR1B

Gene ID

3351

UniProt

P28222

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human 5HT1B/HTR1B recombinant protein (Position: A35-S390) .

Clonality

Polyclonal

Tissue Specificity

Detected adjacent to nodes of Ranvier in juxtaparanodal zones in spinal cord nerve fibers, but also in paranodal regions in some myelinated spinal cord axons (at protein level) (PubMed:11086297) . Detected in the islet of Langerhans (PubMed:21483673) .

Applications

Flow Cytometry

Field of Research

Neuroscience, Stem Cells, Synapse Marker, T Cells, T Lymphocytic Lineage

Purification

Immunogen affinity purified.

Form

Liquid

Function

May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.

References & Citations

1. Bartsch, T., Knight, Y. E., Goadsby, P. J. Activation of 5-HT (1B/1D) receptor in the periaqueductal gray inhibits nociception. Ann. Neurol. 56: 371-381, 2004. 2. Demchyshyn, L., Sunahara, R. K., Miller, K., Teitler, M., Hoffman, B. J., Kennedy, J. L., Seeman, P., Van Tol, H. H. M., Niznik, H. B. A human serotonin 1D receptor variant (5HT1D-beta) encoded by an intronless gene on chromosome 6. Proc. Nat. Acad. Sci. 89: 5522-5526, 1992. 3. Garcia-Nafria, J., Nehme, R., Edwards, P. C., Tate, C. G. Cryo-EM structure of the serotonin 5-HT (1B) receptor coupled to heterotrimeric G (o) . Nature 558: 620-623, 2018.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

18080 MW

Applications Notes

6

Gene Name Synonym

Thy-1 cell surface antigen

Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor.

Protein Name

Thy-1 membrane glycoprotein

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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