Anti-Alanine Transaminase/Gpt Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
This gene encodes cytosolic alanine aminotransaminase 1 (ALT1) ; also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase
Synonyms
Pituitary homeobox 2; ALL1-responsive protein ARP1; Homeobox protein PITX2; Paired-like homeodomain transcription factor 2; RIEG bicoid-related homeobox transcription factor; Solurshin; PITX2; ARP1, RGS, RIEG, RIEG1
Gene Name
Gpt
Gene ID
76282
UniProt
Q8QZR5
Host
Rabbit
Reactivity
Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived mouse Alanine Transaminase/Gpt recombinant protein (Position: A2-S496) .
Clonality
Polyclonal
Tissue Specificity
Isoform 1 is expressed in neurons of the cerebellum and hippocampus. Isoform 2 is expressed in thymus, spleen and lung.
Applications
Flow Cytometry
Field of Research
Cytokines, Immunology, Innate Immunity, Interleukins
Purification
Immunogen affinity purified.
Form
Liquid
Function
Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. IsoformPTX2Cis involved in left-right asymmetry the developing embryo (By similarity) .
References & Citations
1. Astrin, K. H., Arredondo-Vega, F. X., Desnick, R. J., Smith, M. Assignment of the gene for cytosolic alanine aminotransferase (AAT1) to human chromosome 8. Ann. Hum. Genet. 46: 125-133, 1982. 2. Chen, S.-H., Giblett, E. R. Polymorphism of soluble glutamic-pyruvic transaminase: a new genetic marker in man. Science 173: 148-149, 1971. 3. Cook, P. J. L., Jeremiah, S. J., Buckton, K. E. Exclusion mapping of GPT. (Abstract) Cytogenet. Cell Genet. 32: 258 only, 1982.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
141435 MW
Applications Notes
6
Gene Name Synonym
Pituitary homeobox 2
Subcellular Location
Secreted .
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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