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Anti-Gephyrin/GPHN Antibody Picoband® Fluoro647 Conjugated

Selected Variant

A04560-1-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

Gephyrin is a protein that in humans is encoded by the GPHN gene. This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described; however, the full-length nature of all transcript variants is not currently known.

Synonyms

Lymphotactin; C motif chemokine 1; Cytokine SCM-1; Lymphotaxin; Small-inducible cytokine C1; Xcl1; Lptn; Ltn; Scyc1

Gene Name

GPHN

Gene ID

10243

UniProt

Q9NQX3

Host

Rabbit

Reactivity

Human, Mouse, Rat, Monkey

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Gephyrin/GPHN recombinant protein (Position: K148-L736) .

Clonality

Polyclonal

Tissue Specificity

Expressed in activated CD8 (+) T cells. In the thymus, expressed by medullary thymic epithelial cells.

Applications

Flow Cytometry

Field of Research

Chemokines, Immunology, Innate Immunity

Purification

Immunogen affinity purified.

Form

Liquid

Function

Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment.

References & Citations

1. Butler, M. H., Hayashi, A., Ohkoshi, N., Villmann, C., Becker, C.-M., Feng, G., De Camilli, P., Solimena, M. Autoimmunity to gephyrin in stiff-man syndrome. Neuron 26: 307-312, 2000. 2. Eguchi, M., Eguchi-Ishimae, M., Greaves, M. The small oligomerization domain of gephyrin converts MLL to an oncogene. Blood 103: 3876-3882, 2004. 3. Eguchi, M., Eguchi-Ishimae, M., Seto, M., Morishita, K., Suzuki, K., Ueda, R., Ueda, K., Kamada, N., Greaves, M. GPHN, a novel partner gene fused to MLL in a leukemia with t (11;14) (q23; q24) . Genes Chromosomes Cancer 32: 212-221, 2001.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Applications Notes

6

Gene Name Synonym

Chemokine (C motif) ligand 1

Subcellular Location

Secreted.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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