Anti-Gbp2 Antibody Picoband® Fluoro594 Conjugated

Product Specifications

Background

Interferon-induced guanylate-binding protein 2 is a protein that in humans is encoded by the GBP2 gene. This gene belongs to the guanine-binding protein (GBP) family, which includes interferon-induced proteins that can bind to guanine nucleotides (GMP, GDP and GTP) . The encoded protein is a GTPase which hydrolyzes GTP, predominantly to GDP. The protein may play a role as a marker of squamous cell carcinomas.

Synonyms

Activator of 90 kDa heat shock protein ATPase homolog 1; AHA1; p38; AHSA1; C14orf3; HSPC322

Gene Name

Gbp2

Gene ID

14469

UniProt

Q9Z0E6

Host

Rabbit

Reactivity

Mouse

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived mouse Gbp2 recombinant protein (Position: R181-L589) .

Clonality

Polyclonal

Tissue Specificity

Expressed in numerous tissues, including brain, heart, skeletal muscle and kidney and, at lower levels, liver and placenta.

Applications

Flow Cytometry

Field of Research

Chaperones, Golgi Proteins, Protein Trafficking, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360) .

References & Citations

1. Cheng, Y.-S. E., Patterson, C. E., Staeheli, P. Interferon-induced guanylate-binding proteins lack an N (T) KXD consensus motif and bind GMP in addition to GDP and GTP. Molec. Cell. Biol. 11: 4717-4725, 1991. 2. Kim, B.-H., Shenoy, A. R., Kumar, P., Das, R., Tiwari, S., MacMicking, J. D. A family of IFN-gamma-inducible 65-kD GTPases protects against bacterial infection. Science 332: 717-721, 2011. 3. Olszewski, M. A., Gray, J., Vestal, D. J. In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters. J. Interferon Cytokine Res. 26: 328-352, 2006.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

101272 MW

Applications Notes

Gene Name Synonym

Activator of HSP90 ATPase activity 1

Subcellular Location

Cytoplasm, cytosol.

Protein Name

N-alpha-acetyltransferase 15, NatA auxiliary subunit

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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Anti-Gbp2 Antibody Picoband® Fluoro594 Conjugated

Product Specifications

Background

Synonyms

Gene Name

Gene ID

UniProt

Host

Reactivity

Cross Reactivity

Immunogen

Clonality

Tissue Specificity

Applications

Field of Research

Purification

Form

Function

References & Citations

Storage Conditions

Calculated Molecular Weight

Applications Notes

Gene Name Synonym

Subcellular Location

Protein Name

Isotype

Contents

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