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Anti-NXN/NRX Antibody Picoband® Fluoro594 Conjugated

Product Specifications

Background

This gene encodes a member of the thioredoxin superfamily, a group of small, multifunctional redox-active proteins. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. The encoded protein acts a redox-dependent regulator of the Wnt signaling pathway and is involved in cell growth and differentiation.

Synonyms

BMP and activin membrane-bound inhibitor homolog; Non-metastatic gene A protein; Putative transmembrane protein; NMA; BAMBI; NMA

Gene Name

NXN

Gene ID

64359

UniProt

Q6DKJ4

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human NXN/NRX recombinant protein (Position: E19-I435) .

Clonality

Polyclonal

Tissue Specificity

Expressed in adult liver.

Applications

Flow Cytometry

Field of Research

Atherosclerosis, Cardiovascular, Chaperones, Heat Shock Proteins, Protein Trafficking, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Negatively regulates TGF-beta signaling.

References & Citations

1. Hartz, P. A. Personal Communication. Baltimore, Md. 6/30/2009. 2. Kurooka, H., Kato, K., Minoguchi, S., Takahashi, Y., Ikeda, J., Habu, S., Osawa, N., Buchberg, A. M., Moriwaki, K., Shisa, H., Honjo, T. Cloning and characterization of the nucleoredoxin gene that encodes a novel nuclear protein related to thioredoxin. Genomics 39: 331-339, 1997 3. White, J. J., Mazzeu, J. F., Coban-Akdemir, Z., Bayram, Y., Bahrambeigi, V., Hoischen, A., van Bon, B. W. M., Gezdirici, A., Gulec, E. Y., Ramond, F., Touraine, R., Thevenon, J., and 24 others. WNT signaling perturbations underlie the genetic heterogeneity of Robinow syndrome. Am. J. Hum. Genet. 102: 27-43, 2018.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

17136 MW

Applications Notes

6

Gene Name Synonym

BMP and activin membrane bound inhibitor

Subcellular Location

Cytoplasm . Nucleus . Translocates to nuclear foci during heat shock.

Protein Name

Chromaffin granule amine transporter

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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