Anti-KIF2A Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Kinesin-like protein KIF2A is a protein that in humans is encoded by the KIF2A gene. The protein encoded by this gene is a plus end-ed motor required for normal mitotic progression. The encoded protein is required for normal spindle activity during mitosis and is necessary for normal brain development. Several transcript variants encoding different isoforms have been found for this gene.
Synonyms
Intercellular adhesion molecule 2; ICAM-2; CD102; ICAM2
Gene Name
KIF2A
Gene ID
3796
UniProt
O00139
Host
Rabbit
Reactivity
Human, Mouse, Rat, Monkey
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human KIF2A recombinant protein (Position: A2-L706) .
Clonality
Polyclonal
Tissue Specificity
Highly expressed in lung. Also detected in pancreas, kidney, small intestine, ovary, testis, prostate and mammary gland. In lung, it is found in alveolar type II cells but not in bronchiolar epithelium.
Applications
Flow Cytometry
Field of Research
Cell Type Markers, Hematopoietic Progenitors, Immunology, Lymphoid, Stem Cells, T Lymphocytic Lineage
Purification
Immunogen affinity purified.
Form
Liquid
Function
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) . ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen- specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
References & Citations
1. Debernardi, S., Fontanella, E., De Gregorio, L., Pierotti, M. A., Delia, D. Identification of a novel human kinesin-related gene (HK2) by the cDNA differential display technique. Genomics 42: 67-73, 1997. 2. Gross, M. B. Personal Communication. Baltimore, Md. 9/18/2013. 3. Homma, N., Takei, Y., Tanaka, Y., Nakata, T., Terada, S., Kikkawa, M., Noda, Y., Hirokawa, N. Kinesin superfamily protein 2A (KIF2A) functions in suppression of collateral branch extension. Cell 114: 229-239, 2003.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Intercellular adhesion molecule 2
Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Name
Eukaryotic initiation factor 4A-I
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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