Anti-KHSRP Antibody Picoband® Fluoro647 Conjugated

Far upstream element-binding protein 2 is a protein that in humans is encoded by the KHSRP gene. The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization.

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development (PubMed:19956738, PubMed:24899501) . Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region.

1. Briata, P., Forcales, S. V., Ponassi, M., Corte, G., Chen, C.-Y., Karin, M., Puri, P. L., Gherzi, R. p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts. Molec. Cell 20: 891-903, 2005. 2. Davis-Smyth, T., Duncan, R. C., Zheng, T., Michelotti, G., Levens, D. The far upstream element-binding proteins comprise an ancient family of single-strand DNA-binding transactivators. J. Biol. Chem. 271: 31679-31687, 1996. 3. Gherzi, R., Lee, K.-Y., Briata, P., Wegmuller, D., Moroni, C., Karin, M., Chen, C.-Y. A KH domain RNA binding protein, KSRP, promotes ARE-ed mRNA turnover by recruiting the degradation machinery. Molec. Cell 14: 571-583, 2004.

Alpha-beta T cell receptor complex; external side of plasma membrane; immunological synapse; cell body; cell-cell junction; dendritic spine; integral component of membrane