Anti-EIF5 Antibody Picoband® Fluoro550 Conjugated
Product Specifications
Background
Eukaryotic translation initiation factor 5 is a protein that in humans is encoded by the EIF5 gene. Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of bound GTP with concomitant joining of the 60S ribosomal subunit to the 40S initiation complex. The resulting functional 80S ribosomal initiation complex is then active in peptidyl transfer and chain elongations.
Synonyms
Type I iodothyronine deiodinase; 5DI; DIOI; Type 1 DI; Type-I 5'-deiodinase; DIO1; ITDI1; TXDI1
Gene Name
EIF5
Gene ID
1983
UniProt
P55010
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human EIF5 recombinant protein (Position: D11-D423) .
Clonality
Polyclonal
Tissue Specificity
Widely expressed in adult (at protein level) and fetal tissues.
Applications
Flow Cytometry
Field of Research
Cancer, Oncoproteins/Suppressors, Tumor Suppressors
Purification
Immunogen affinity purified.
Form
Liquid
Function
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine) . Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney.
References & Citations
1. Das, S., Ghosh, R., Maitra, U. Eukaryotic translation initiation factor 5 functions as a GTPase-activating protein. J. Biol. Chem. 276: 6720-6726, 2001. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 5/5/2010. 3. Jennings, M. D., Pavitt, G. D. eIF5 has GDI activity necessary for translational control by eIF2 phosphorylation. Nature 465: 378-381, 2010. Note: Erratum: Nature 468: 122 only, 2010.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Iodothyronine deiodinase 1
Subcellular Location
Endoplasmic reticulum membrane. Single-pass membrane protein.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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