Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-DIAPH1 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Protein diaphanous homolog 1 is a protein that in humans is encoded by the DIAPH1 gene. This gene is a homolog of the Drosophila diaphanous gene, and has been linked to autosomal dominant, fully penetrant, nonsyndromic sensorineural progressive low-frequency hearing loss. Actin polymerization involves proteins known to interact with diaphanous protein in Drosophila and mouse. It has therefore been speculated that this gene may have a role in the regulation of actin polymerization in hair cells of the inner ear. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Synonyms

Adrenocorticotropic hormone receptor; ACTH receptor; ACTH-R; Adrenocorticotropin receptor; Melanocortin receptor 2; MC2-R; MC2R; ACTHR

Gene Name

DIAPH1

Gene ID

1729

UniProt

O60610

Host

Rabbit

Reactivity

Human, Monkey

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human DIAPH1 recombinant protein (Position: D1039-Q1153) .

Clonality

Polyclonal

Tissue Specificity

Melanocytes and corticoadrenal tissue.

Applications

Flow Cytometry

Field of Research

Cancer, Cardiovascular, Cholesterol Metabolism, Endocrine System, G Protein Signaling, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Lipids/Lipoproteins, Metabolic Signaling Pathways, Metabolism, More Gpcr, Neuroscience, Neurotransmission, Pathways and Processes, Receptors / Channels, Signal Transduction, Signaling Pathway

Purification

Immunogen affinity purified.

Form

Liquid

Function

Receptor for corticotropin (ACTH) . This receptor is mediated by G proteins (G (s) ) which activate adenylate cyclase (cAMP) . .

References & Citations

1. Al-Maawali, A., Barry, B. J., Rajab, A., El-Quessny, M., Seman, A., Coury, S. N., Barkovich, A. J., Yang, E., Walsh, C. A., Mochida, G. H., Stoler, J. M. Novel loss-of-function variants in DIAPH1 associated with syndromic microcephaly, blindness, and early onset seizures. Am. J. Med. Genet. 170A: 435-440, 2016. 2. Carreira, S., Goodall, J., Denat, L., Rodriguez, M., Nuciforo, P., Hoek, K. S., Testori, A., Larue, L., Goding, C. R. Mitf regulation of Dia1 controls melanoma proliferation and invasiveness. Genes Dev. 20: 3426-3439, 2006. 3. Ercan-Sencicek, A. G., Jambi, S., Franjic, D., Nishimura, S., Li, M., El-Fishawy, P., Morgan, T. M., Sanders, S. J., Bilguvar, K., Suri, M., Johnson, M. H., Gupta, A. R., Yuksel, Z., Mane, S., Grigorenko, E., Picciotto, M., Alberts, A. S., Gunel, M., Sestan, N., State, M. W. Homozygous loss of DIAPH1 is a novel cause of microcephaly in humans. Europ. J. Hum. Genet. 23: 165-172, 2015.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

33927 MW

Applications Notes

6

Gene Name Synonym

Adrenocorticotropic hormone receptor

Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Name

Adrenocorticotropic hormone receptor

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

2-Hexadecyloxyethanol
TRC-H291030-1G 1 g

2-Hexadecyloxyethanol

Ask
View Details
HPSE2 (NM_021828) Human Over-expression Lysate
LY411910 100 µg

HPSE2 (NM_021828) Human Over-expression Lysate

Ask
View Details
Rabbit anti-SYNE1/CPG2/Nesprin 1 Antibody, Affinity Purified
MBS3905204-01 0.01 mg

Rabbit anti-SYNE1/CPG2/Nesprin 1 Antibody, Affinity Purified

Ask
View Details
Rabbit anti-SYNE1/CPG2/Nesprin 1 Antibody, Affinity Purified
MBS3905204-02 0.1 mg

Rabbit anti-SYNE1/CPG2/Nesprin 1 Antibody, Affinity Purified

Ask
View Details
Rabbit anti-SYNE1/CPG2/Nesprin 1 Antibody, Affinity Purified
MBS3905204-03 5x 0.01 mg

Rabbit anti-SYNE1/CPG2/Nesprin 1 Antibody, Affinity Purified

Ask
View Details
Rabbit anti-SYNE1/CPG2/Nesprin 1 Antibody, Affinity Purified
MBS3905204-04 5x 0.1 mg

Rabbit anti-SYNE1/CPG2/Nesprin 1 Antibody, Affinity Purified

Ask
View Details