Anti-ZIP Kinase/Dapk3 Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Death-associated protein kinase 3 is an enzyme that in humans is encoded by the DAPK3 gene. Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis.
Synonyms
Glutathione S-transferase Mu 3; GST class-mu 3; GSTM3-3; hGSTM3-3; GSTM3; GST5
Gene Name
Dapk3
Gene ID
13144
UniProt
O54784
Host
Rabbit
Reactivity
Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived mouse ZIP Kinase/Dapk3 recombinant protein (Position: R290-R448) .
Clonality
Polyclonal
Tissue Specificity
Testis and brain.
Applications
Flow Cytometry
Field of Research
Cancer, Drug Metabolism, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers.
References & Citations
1. Kawai, T., Matsumoto, M., Takeda, K., Sanjo, H., Akira, S. ZIP kinase, a novel serine/threonine kinase which mediates apoptosis. Molec. Cell. Biol. 18: 1642-1651, 1998. 2. Mukhopadhyay, R., Ray, P. S., Arif, A., Brady, A. K., Kinter, M., Fox, P. L. DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression. Molec. Cell 32: 371-382, 2008. 3. Saito, T., Seki, N., Ohira, M., Hayashi, A., Kozuma, S., Hattori, A., Hori, T. Assignment of the ZIP kinase gene to human chromosome 19p13.3 by somatic hybrid analysis and fluorescence in-situ hybridization. J. Hum. Genet. 43: 209-211, 1998.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Applications Notes
6
Gene Name Synonym
Glutathione S-transferase mu 3
Subcellular Location
Cytoplasm.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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