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Anti-Steroid sulfatase/STS Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Steroid sulfatase (STS), or steryl-sulfatase, formerly known as arylsulfatase C, is a sulfatase enzyme involved in the metabolism of steroids. It is encoded by the STS gene. This gene encodes a multi-pass membrane protein that is localized to the endoplasmic reticulum. It belongs to the sulfatase family and hydrolyzes several 3-beta-hydroxysteroid sulfates, which serve as metabolic precursors for estrogens, androgens, and cholesterol. Mutations in this gene are associated with X-linked ichthyosis (XLI) . Alternatively spliced transcript variants resulting from the use of different promoters have been described for this gene.

Synonyms

Steryl-sulfatase; Arylsulfatase C; ASC; Steroid sulfatase; Steryl-sulfate sulfohydrolase; STS; ARSC1

Gene Name

STS

Gene ID

412

UniProt

P08842

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human STS recombinant protein (Position: K297-Q547) .

Clonality

Polyclonal

Tissue Specificity

Ubiquitously expressed. Highest expression in heart, stomach, bladder and small intestine. .

Applications

Flow Cytometry

Field of Research

Adapters, Adaptive Immunity, Cell Biology, Immunology, Proteasome / Ubiquitin, Protein Trafficking, Proteolysis/Ubiquitin, Signal Transduction, T Cells, Vesicle Transport

Purification

Immunogen affinity purified.

Form

Liquid

Function

Conversion of sulfated steroid precursors to estrogens during pregnancy.

References & Citations

1. Entrez Gene: STS steroid sulfatase (microsomal), arylsulfatase C, isozyme S. 2. Alperin ES, Shapiro LJ (August 1997) . Characterization of point mutations in patients with X-linked ichthyosis. Effects on the structure and function of the steroid sulfatase protein. The Journal of Biological Chemistry. 272 (33) : 20756–63. 3. Rižner TL (2016) . The Important Roles of Steroid Sulfatase and Sulfotransferases in Gynecological Diseases. Frontiers in Pharmacology. 7: 30.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

21405 MW

Applications Notes

6

Gene Name Synonym

Steroid sulfatase

Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Protein Name

Cytoglobin

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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