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Anti-SOX17 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

SRY-box 17 is a protein that in humans is encoded by the SOX17 gene. This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins.

Synonyms

Deoxycytidine kinase; dCK; DCK

Gene Name

SOX17

Gene ID

64321

UniProt

Q9H6I2

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human SOX17 recombinant protein (Position: M1-V414) .

Clonality

Polyclonal

Tissue Specificity

Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin mainly in epithelial cells (at protein level) .

Applications

Flow Cytometry

Field of Research

Cancer, Cell Cycle, Kinases/Phosphatases, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA) . Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.

References & Citations

1. Gimelli, S., Caridi, G., Beri, S., McCracken, K., Bocciardi, R., Zordan, P., Dagnino, M., Fiorio, P., Murer, L., Benetti, E., Zuffardi, O., Giorda, R., Wells, J. M., Gimelli, G., Ghiggeri, G. M. Mutations in SOX17 are associated with congenital anomalies of the kidney and the urinary tract. Hum. Mutat. 31: 1352-1359, 2010. 2. Heidet, L., Moriniere, V., Henry, C., De Tomasi, L., Reilly, M. L., Humbert, C., Alibeu, O., Fourrage, C., Bole-Feysot, C., Nitschke, P., Tores, F., Bras, M., and 13 others. Targeted exome sequencing identifies PBX1 as involved in monogenic congenital anomalies of the kidney and urinary tract. J. Am. Soc. Nephrol. 28: 2901-2914, 2017. 3. Kanai, Y., Kanai-Azuma, M., Noce, T., Saido, T. C., Shiroishi, T., Hayashi, Y., Yazaki, K. Identification of two Sox17 messenger RNA isoforms, with and without the high mobility group box region, and their differential expression in mouse spermatogenesis. J. Cell Biol. 133: 667-681, 1996.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

50514 MW

Applications Notes

6

Gene Name Synonym

Deoxycytidine kinase

Subcellular Location

Nucleus.

Protein Name

Carboxypeptidase M

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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